We found that vitamin D has a preventive effect on CRC at the genetic level [14], a result that concurs with those obtained by Ferrer-Mayorga et al. [34] who concluded that 1,25(OH)2 D3 protects against CRC by regulating intestinal stromal fibroblasts, suggesting that the expression of VDR and vitamin D-related genes in these cells could be the reason behind this protective effect [34]. Here, VDR is linked to colorectal carcinoma.