Further evaluation of the 3,5-dimethoxy (1308) and 3,4,5-trimethoxy derivatives (1309) in chronic lymphocytic leukemia cells revealed that cotreatment of 1α,25-dihydroxyvitamin D3 and inhibitor upregulated GADD45α (growth arrest and DNA damage 45 gen) and CDKN1A (cyclin-dependent kinase inhibitor 1A gen). The gene discussed is CDKN1A; the disease is B-cell chronic lymphocytic leukemia.