2-Methylene-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol 942 [20(S)-2MbisP] [263] were able to suppress PTH at levels that did not stimulate bone resorption, intestinal calcium, or phosphate absorption and may have potential for use in the treatment of 2HPT in chronic kidney disease. The gene discussed is PTH; the disease is chronic kidney disease.