Then, they subdivided the samples in two groups based on insulin resistance: four low insulin resistant obese individuals (49.5 ± 5.2 kg/m2, 39.0 ± 13.1 years, losing ~17.6 kg/m2 after 2 years) and four high insulin resistant obese individuals (52.2 ± 6.8 kg/m2, 43.2 ± 10.7 years and losing ~15.6 kg/m2 after 2 years). The gene discussed is INS; the disease is Insulin resistance.