Additionally, our findings suggest that the reduced oxidative stress as well as lipid peroxidation, decreased iron deposition, and restoration of intestinal microbial diversity via L. lactis MG1363-pMG36e-GLP-1 are of significance for inhibiting ferroptosis, providing a putative pharmaceutic drug for clinical prophylaxis and treating PD. The gene discussed is GLP1R; the disease is Parkinson disease.