Herein, we continued to study the neurotrophic role of next-generation probiotic strain L. lactis MG1363-pMG36e-GLP-1 on MPTP-induced PD mice model by intragastric administration and determined the neuroprotection and neurotrophy mediated by suppression of DAergic neuronal ferroptosis. This evidence concerns the gene GLP1R and Parkinson disease.