On the other hand, a series of studies report the effect of some natural compounds on the expression of cyclin D1 in models of colorectal cancer, such as diospyros kaki thunb (DKC), which decreased protein and mRNA levels at concentrations of 50 μg/mL, mainly in SW480 cells, after 24 h [51]. This evidence concerns the gene CCND1 and colorectal cancer.