It is also pivotal to identify women at high risk of severe hypoglycaemia, i.e., women who have a history with severe hypoglycaemia in the year preceding pregnancy, impaired hypoglycaemia awareness, long duration of diabetes, HbA1c < 48 mmol/mol (6.5%) in early pregnancy, fluctuating plasma glucose values, and excessive use of supplementary insulin injections between meals. This evidence concerns the gene INS and Hypoglycemia.