Lactobacillus rhamnosus hsryfm 1301 fermented milk may also inhibit Ca2+ concentration by suppressing transcription of P2rx1, which, in turn, inhibits transcription of Prkcg, alleviating lipid metabolism disorders by regulating immune, signal transduction and digestive system pathways while alleviating insulin hypersecretion and hypothyroidism caused by high-fat diet. This evidence concerns the gene P2RX1 and hypothyroidism.