AKT1 and Alzheimer disease: In addition, G. lucidum polysaccharides have been shown to regulate NDs, such as AD and epilepsy, by modulating OS/related pathways, including extracellular regulated protein kinase (ERK)/protein kinase B (Akt) signaling, c-Jun N-terminal kinase (JNK)/mitogen activated protein kinase (MAPK) signaling, and NF-κB signaling [63,64,65].