BCHE and Alzheimer disease: At present, the main drugs for the treatment of AD include cholinesterase inhibitors (such as galantamine, memantine, rivastigmine, donepezil, and tacrine) [7], antioxidant drugs (such as melatonin and monoamine oxidase inhibitors) [8,9], calcium channel blockers (such as flunarizine, nimodipine, nilvadipine, and nitrendipine) [10], and drugs directed at β1 amyloid (such as MK-8931 and E2069) [11].