Increase cell survival, induce cell differentiation, block intracellular Ca2+ overload, inhibit ROS production and prevent MMP depolarization in L-Glu induced HT22 cell apoptosis model; reduce the apoptosis rate, Aβ deposition, oxidative damage, and p-Tau aggregations in the hippocampus of AD mouse. Here, MAPT is linked to Alzheimer disease.