ACPS, a polysaccharide isolated from Amanita caesarea, was confirmed to exhibit significant anti-AD effects and neuroprotective activities via the regulation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated OS in both L-glutamine (Glu)-exposed HT22 cells and in AD mice induced by D-Gal and AlCl3 [60]. The gene discussed is NFE2L2; the disease is Alzheimer disease.