Pb exposure has also caused insulin resistance and metabolism disorder in the livers of experimental animals by regulating the activity of glycogenolysis and gluconeogenesis enzymes, including hexokinase (HK), pyruvate kinase (PK), glucokinase (GK), phosphoenolpyruvate carboxy kinase (PEPCK) and glucose-6-phosphate dehydrogenase (G6PD) [3,9,10]. The gene discussed is G6PD; the disease is metabolic disease.