Powe et al. showed utilizing data from two cohorts (Genetics of Glucose Regulation in Gestation, n = 573, and Hyperglycemia and Adverse Pregnancy Outcomes (HAPO), n = 4431) that genetic risk scores for elevated fasting glucose and insulin, reduced insulin secretion and sensitivity, and T2D, built using SNPs linked to glycemic traits in non-pregnant populations, were also associated with these traits during pregnancy [109]. This evidence concerns the gene INS and type 2 diabetes mellitus.