Moreover, in another study in which authors compared early eating (between 08:00–18:00) with isocaloric late eating (between 13:00–23:00) in adults with overweight and obesity, late eating led to higher waketime hunger, decreased energy expenditure and serum leptin (which promotes satiety) and increased ghrelin to leptin ratio [71]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.