TARDBP and amyotrophic lateral sclerosis: Aggregation of proteins and peptides into their pathological forms are the key events in NDDs [5], for example, amyloid beta protein (Aβ) and Tau in AD [6]; mutant huntingtin (mHTT) protein in HD [7]; α-synuclein (αSN) in PD and TAR DNA-binding protein 43 (TDP-43) in ALS [8].