The oral administration of linalool (25 mg/kg for 3 months) in a triple transgenic AD mouse model (3xTg-AD) restored memory in the treated animals via reducing β-amyloidosis, astrogliosis, and tauopathy besides reducing proinflammatory markers (MAPK, inducible oxide nitric synthase (iNOS), COX-2, IL-1β) [159]. This evidence concerns the gene NOS2 and Alzheimer disease.