Although Nrf2 has been shown to be an important mediator of NLRP3 and AIM2 inflammasome activation and also plays a promoting role in atherosclerosis (type II diabetes mellitus associated with chronic inflammation), it has also been shown that Nrf2 has a protective role in sepsis, asthma, infectious diseases, and other diseases [27]. Here, AIM2 is linked to atherosclerosis.