The following conditions are considered indicators of nutritional intervention: anorexia or poor oral intake; protein intake < 1.2 g/kg/day (CKD stage 5D) or <0.7 g/kg/day (CKD stages 3–4); energy intake < 30 kcal/kg/day; serum albumin < 3.8 g/dL or serum pre-albumin level < 28 mg/dL; unintentional weight loss over 3 months > 5% of ideal weight or estimated dry weight; worsening nutritional markers over time; and subjective global assessment reaching the PEW range. This evidence concerns the gene ALB and chronic kidney disease.