Several signaling pathways are involved in the mechanism of polyphenols against skin cancer metastasis, including NF-κB, epidermal growth factor receptor/mitogen activated protein kinase (EGFR/MAPK), and phosphatidylinositide 3- kinases/protein kinase B (PI3K/Akt) [83,84]. The gene discussed is AKT1; the disease is skin cancer.