CASP3 and breast cancer: Our findings revealed that the expression of bax (a pro-apoptotic factor), cleaved caspase 3 and c-PARP proteins were substantially increased, while the expression of bcl2 (an anti-apoptotic factor) was decreased in both MCF-7 and MDA-MB-231 breast cancer cell lines by azilsartan leading to the induction of apoptosis, as summarized in Figure 11, which was also confirmed by the flow cytometric analysis.