To confirm the role of azilsartan in targeting NF-kB pathway and initiating apoptosis in MCF-7 and MDA-MB-231 breast cancer cells, cells were stimulated with TNFα after the treatment with the IC50 of azilsartan and the levels of NF-kB p65 and cleaved caspase 3 proteins were measured. This evidence concerns the gene CASP3 and breast cancer.