In this study, the protective effects of RA pretreatment on CP-induced ALI and AKI in mice were investigated for the first time through in vivo experiments, and it was confirmed that RA could inhibit inflammatory responses and antioxidant levels, which in turn activated genes related to the Nrf2 signaling pathway and reversed drug-induced hepatic and renal injury. The gene discussed is NFE2L2; the disease is acute respiratory distress syndrome.