Quercetin further showed anti-metastatic activity against light/dark shift-induced metastasis in BJMC3879Luc2 mouse breast cancer cells transplanted into BALB/c mice [56], and was proven to affect circadian clock and age-related genes in fibroblast cells [57].and The flavonol is thought to have anti-obesity activity through the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway [58], a pathway also known to be influenced by variations in the circadian clock [59]. The gene discussed is CLOCK; the disease is obesity due to melanocortin 4 receptor deficiency.