The ability to induce cell death on the MCF-7 cell line of both crude extracts and their Aq-fractions revealed a cytotoxic effect by inducing cancer cell apoptosis, with 88%, 85%, 59% and 47% of cells positive to annexin V-FITC for EHA and Aq crude extracts, and EHA-Aq and Aq-Aq fractions, respectively, with only 12% for control cells (Figure 1A,B). Here, ANXA5 is linked to cancer.