In a secondary screen, we identified MMRi62 to be a modifier of the MDM2-MDM4 E3 ligase activity, inducing MDM4 degradation in cells and p53-independent apoptosis in leukemic cells [22], as well as ferroptosis in pancreatic cancers associated with the degradation of FTH1 (Ferritin Heavy Chain 1) [23]. Here, MDM4 is linked to pancreatic neoplasm.