FNDC5 and osteoarthritis, hip: In contrast, similar irisin levels were reported between women with incident hip fractures sampled right before fixation, and the controls were post-menopausal women with knee or hip osteoarthritis schedules for arthroplasty [53], while even higher irisin levels post-fracture were reported in a study prospectively evaluating 21 patients with low extremity fractures for 60 days [54].