A number of inflammatory cytokines, most notably interleukin-6 (IL)-6, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), were identified as major players in the pathogenesis of RA as well as RA-related comorbidities, such as osteoporosis [108]. The gene discussed is IL1B; the disease is rheumatoid arthritis.