Other interventional studies have shown that periodontitis therapy can have beneficial effects on systemic health parameters in average weight or patients with obesity, such as lowering blood pressure [50,121], improving diastolic cardiac function [122], endothelial dysfunction [52,123], inflammatory markers (CRP, TNF α, IL1-b) [49,50,55], lipid profile [54], diabetes parameter [49] and improves glycemic control [53]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.