The locations and distributions of SORD variants in our study are presented in Figure 1B. For the missense variants detected in ALS patients, variant (c.244T > A, p.Ser82Thr) was located in the Zinc binding domain, and variant (c.728A > G, p.Lys243Arg) was located in the tetramer interface domain. This evidence concerns the gene SORD and amyotrophic lateral sclerosis.