SMARCB1 and neoplasm: SWI/SNF tumor suppressor proteins act as antagonists of the polycomb enhancer gene of zeste homolog 2 (EZH2), whereby the EZH2 oncogene is constitutively activated in INI-1-deficient tumors and regulates histone methylation resulting in tumor-suppressor gene silencing, oncogenic transformation, metastasis development, and drug resistance [75,76,77].