In particular, patients with microscopic hematuria who had persistent proteinuria (>1.0 g/day) had an increased risk of renal failure, consistent with previous research [14], and patients with microscopic hematuria with persistent hypoalbuminemia (TA-serum albumin < 40 g/L) also had a greater risk of renal failure. The gene discussed is ALB; the disease is Renal insufficiency.