The most significant net benefit in predicting both developing PMI and/or in-hospital mortality demonstrated preoperative GGT/ALT ratio > 2.5, elevated urea (>7.5 mmol/L), hyperparathyroidism (PTH > 6.8 pmol/L) and abnormal vitamin D status (deficiency or insufficiency); preoperative Urea/Albumin ≥ 2.0 strongly indicated risk of PMI, and hypoalbuminaemia (<33 g/L)—a high risk of a lethal outcome. The gene discussed is ALB; the disease is Hypoalbuminemia.