There are three major causative genes for FH: low-density lipoprotein receptor (LDLR: accounting for 80–85 % of the factors leading to LDL metabolism disorders), apolipoprotein B100 (apoB100, 5–10%), and proprotein convertase subtilisin/kexin type 9 (PCSK9, 2%) [2]. The gene discussed is PCSK9; the disease is familial hyperaldosteronism.