In the case of p53 mutations, the prognosis for the patient appears to be poor: abnormal p53 tumors expression is categorized as follows: strong positive p53 expression in >80% of the tumor nuclei (mutant overexpression), complete absence of p53 expression with a positive internal control (null mutant), or significant cytoplasmic p53 expression (cytoplasmic) in >80% of the tumors. This evidence concerns the gene TP53 and neoplasm.