Consistently, the activities of mitochondrial respiratory complexes [79,120], as well as pyruvate dehydrogenase complex, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase and ATP synthase activities were found to be reduced [63]: this state of affairs is associated with mitochondrial impairment of Δψm and OXPHOS [121], reduced intracellular ATP levels and increased OS [122], which intensifies deposition of amyloid aggravating cognitive dysfunction in AD mice and contributes to the phosphorylation and polymerization of Tau [123]. This evidence concerns the gene MAPT and Alzheimer disease.