The Aβ peptides themselves interact with an NH2-derived neurotoxic Tau fragment of the human Tau40 isoform (441 amino acids) in human AD synapses in association with mitochondrial ANT, a condition that further worsens mitochondrial dysfunction by aggravating the impairment of the ANT, thus leading to a strong energy metabolism deficit [46,54,55]. Here, MAPT is linked to Alzheimer disease.