Xuebijing administration significantly abolished CLP-induced elevations in IL-6 (6 h after CLP), IL-1β (2 and 12 h after CLP), and TNF-α (2, 4, 6, 8, and 12 h after CLP) plasma levels at different time points after CLP (all p < 0.05), suggesting that Xuebijing administration alleviates sepsis-induced systemic inflammation in CLP rats. This evidence concerns the gene TNF and Sepsis.