Since the clinical status of the patient worsened abruptly and was associated with peripheral eosinophilia despite pulse therapy, we decided to “attack” the eosinophils/IL-5 axis with Benralizumab as well as to administer immunomodulatory IVIg and to continue broad-spectrum antibiotics and systemic antifungal agents. The gene discussed is IL5; the disease is Increased total eosinophil count.