In addition, improving the activation of endogenous anti-oxidant factors, including superoxide dismutase (SOD), heme oxygenase 1 (HO-1), glutathione-S-transferase (GST), and glutathione peroxidase (GPX), is considered a promising therapeutic strategy in AKI-induced distant dysfunction [180,181]. The gene discussed is HMOX1; the disease is acute kidney injury.