In addition, ET patients with TET2 mutations had significantly higher D-Dimers, significantly lower AT-III, and a higher percentage of D-Dimers and FDPs above the normal range, which may explain why TET2 mutation is a risk factor for thrombosis in ET patients; however, a larger sample size is needed to demonstrate this association. The gene discussed is SERPINC1; the disease is Venous thrombosis.