Gene-mapped differential methylation is higher in CDF patients, as compared with patients with DM, including hypermethylation (86%), suggesting that circulating monocytes seem to be ‘ready’ for differentiation; second, that they may be involved in monocyte differentiation into osteoclasts, while regarding DNA methylation and gene expression in CDF patients only the PPP2R5D gene had a cis association with expression [46]. This evidence concerns the gene PPP2R5D and diabetes mellitus.