When comparing patients with CDF versus patients with DM and without DM, the inflammatory markers tendency is to show increased levels of IL-6, IL-1β, TNF-α [16,38,39], OPG [16], and serum RANKL (sRANKL) [7], and decreased values for fsRANKL [16] (Table 1). Here, TNFRSF11B is linked to diabetes mellitus.