CYP27A1 and diabetes mellitus: Jansen et al. reported a decrease in CTX (carboxy-terminal collagen crosslinks), at baseline versus follow-up (387 ± 136 versus 95 ± 83 ng/L, p < 0.001) in the DM+CDF group and (305 ± 141 versus 90 ± 40 ng/L, p < 0.001) in the DM-CDF group, but with no difference for osteocalcin (16.9 ± 5.7 versus 14.7 ± 11.5 μg/L, p = 0.153) in the DM+CDF group or, respectively, (11.1 ± 4 versus 10.4 ± 3.6 μg/L, p = 0.695) in the DM-CDF group [15].