ALS is characterized by the infiltration of T-lymphocytes and macrophages in the CNS [129,130,131], immunoglobulins from ALS patients cause the degeneration of mice motor neurons [132,133,134]; the role of the autoimmune inflammation in ALS is further supported by the increased CSF and serum levels of IL-17 and IL-23 produced predominantly by Th17 [135]. This evidence concerns the gene IL17A and amyotrophic lateral sclerosis.