Thus, we suggest that an increase in the expression of the VPS28 gene in subjects with the T2D-associated alleles may demonstrate the increased activation of the ubiquitin–proteasome pathway, a part of the unfolded protein response directed at the degradation of unfolded or misfolded proteins in the ER, the conditions playing a role in the pathogenesis of type 2 diabetes [43,44,45]. Here, VPS28 is linked to type 2 diabetes mellitus.