Apparently, the association of rs7838717 and rs3757971 with T2D risk can be explained by the relationship of these polymorphisms with the expression levels of genes such as VPS28, KIAA1875, TONSL, EPPK1, and BOP1 (these genes were not correlated with SNP rs4279640). This evidence concerns the gene EPPK1 and type 2 diabetes mellitus.