The node degrees of IL6, nitric oxide synthase 3 (NOS3), solute carrier family 6 member 4 (SLC6A4), estrogen receptor (ESR1), and tumor necrosis factor (TNF) were greater than 10, suggesting that these targets could play important roles in the effects of AL on depression (Figure 5B). The gene discussed is ESR1; the disease is major depressive disorder.