As reported in the codominant model, the KLF14-AA genotype was demonstrated to be associated with increased CAD susceptibility with an OR of 2.24, (95%) CI = (1.1070 to 4.5383), RR = 1.66 (1.0358 to 2.6817), and p < 0.024; whereas the KLF14-GA genotype was shown to be a potential protective marker for CAD risk with an OR 0.40, (95%) CI = (0.2237 to 0.7234), and p < 0.002. This evidence concerns the gene KLF14 and coronary artery disorder.