As summarized in Table 4, our results demonstrated that in the codominant model, the MTHFR-TT genotype was associated strongly with increased CAD patient susceptibility with an OR of 2.75, (95%) CI = (1.0018 to 7.5558), RR = 1.80 (0.9084 to 3.5814), and p < 0.049; whereas no association with CAD susceptibility was reported for the MTHFR-CT genotype with an OR of 1.67, (95%) CI = (0.9529 to 2.9393), and p < 0.73. The gene discussed is MTHFR; the disease is coronary artery disorder.