Renal magnesium wasting in ADTKD-HNF1B may be related to the finding that transcription of FXYD2, the γ-subunit of the Na+/K+-ATPase, is regulated by HNF1β in the distal tubule [42]. Here, HNF1B is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.