Key measures of the ER stress response, such as BiP (chaperone ER), ER-degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1), CHOP C/EBP homologous protein, and X-box binding protein 1 (XBP1), are significantly elevated in patients with a major depression disorder [43]. The gene discussed is DDIT3; the disease is major depressive disorder.