There, mtDNA interacts with and activates a variety of immunostimulatory DNA sensors, including cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and Toll-like receptors (TLR7/9), which can trigger autoimmunity by activating IFN-α inflammatory responses [13,15,31]. The gene discussed is CGAS; the disease is Autoimmunity.