Although the information on BTZ resistance in MCL remains largely unknown, attributable in part to its nature as a multifactorial phenomenon, certain characteristics of BTZ-resistant MCL cells have previously been reported, namely uncontrolled plasmacytic differentiation [12], activation of B-cell receptor (BCR) signaling [13], and alteration of lipid metabolism [14]. The gene discussed is CASC3; the disease is mantle cell lymphoma.