Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma (NHL) arising from the pre-germinal center of a mature B cell that is characterized by the presence of translocation t(11;14)(q13;q32) resulting in an aberrant expression of cyclin D1 (encoded by CCND1) and uncontrolled cell growth [1,2]. The gene discussed is CCND1; the disease is non-Hodgkin lymphoma.