Accumulating evidence has indicated that activated Th1 and Th17 cells are capable of producing interleukin (IL)-17, IL-21, IL-22, granulocyte and macrophage colony stimulation factor (GM-CSF), interferon (IFN)-γ, and tumor necrosis factor (TNF)-α, are the main constituents of CD4+ T cells that drive MS development [55,56]. Here, TNF is linked to myeloid sarcoma.