Quantification of the % area showed NLRP3 expression increased in the entire retina from CTL to DM to DR, with significantly higher expression found in DR (780.6 ± 109.1%) compared to CTL (100.0 ± 61.7%; p ≤ 0.0001) and DM (397.6 ± 116.7%, p ≤ 0.05) (Figure 6B). Here, NLRP3 is linked to diabetes mellitus.