Most of the top hubs in the networks are featured in the endocytosis pathway such as the repressed RHOA and SMAD3, and four induced heat shock proteins (i.e., HSPA1A, HSPA1B, HSPA8, and HSPA2), being differently shared with the previous pathways as well as with protein processing in endoplasmatic reticulum, legionellosis and cytokine–cytokine receptor interaction pathways. Here, SMAD3 is linked to legionellosis.