DNMT1 and hepatocellular carcinoma: In vascular endothelial cells, inhibition of mTOR by rapamycin decreases the expression of DNMT1 [50], while in hepatocellular carcinoma cell lines Hep G2, SNU-182, and Hep 3B2.1-7, inhibition of mTOR with Torin-2 increases the expression of DNMT1 [51].