APP and glioma: In order to confirm that NAGLU and dNAGLU are functionally conserved and can indeed degrade Aβ42 in both fly and mammalian cells, we tested NAGLU overexpression in a human glioma cell line, U251-APP cells [36], and detected a 105-fold increase in NAGLU mRNA expression compared to control (Figure 6A, p = 0.0001).