While in the experimental group, the F1 generation obtained by crossing of GS-Gal4>Aβ42 flies and dNAGLU transgenic flies were fed SY food with 200 μM RU486 to induce both the expression of Aβ42 and the overexpression of dNAGLU (i.e., GS-Gal4>Aβ42>dNAGLU +RU flies, in other words, we induced dNAGLU overexpression in Drosophila AD model). The gene discussed is LGALS4; the disease is Alzheimer disease.