Past studies indicated that Morusin can suppress inflammatory signaling in stimulated keratinocytes via inhibiting the signal transducer and activator of transcription 1 (STAT1) and nuclear factor-kappaB (NF-κB) p65 phosphorylation [9], reduce cell proliferation and promote cell apoptosis of osteosarcoma cells by inhibiting the PI3K-AKT signaling pathway [10], and alleviate chemical-induced rat colitis by reducing the production of proinflammatory and fibrosis markers (IL-1β, TGF-β, MMP-2 and 9) [11]. The gene discussed is STAT1; the disease is osteosarcoma.