In summary, the candidate compound PGG can activate the AMPK/PI3K/AKT/Nrf2 antioxidant pathway to reduce the proinflammatory cytokines (IL-6 and IL-1β), the MDA formation and SOD consumption, further lowering the alveolar inflammatory cell infiltration and pulmonary edema, and ultimately ameliorating ALI (Figure 6). This evidence concerns the gene IL6 and acute respiratory distress syndrome.