SOD1 and acute respiratory distress syndrome: In summary, the candidate compound PGG can activate the AMPK/PI3K/AKT/Nrf2 antioxidant pathway to reduce the proinflammatory cytokines (IL-6 and IL-1β), the MDA formation and SOD consumption, further lowering the alveolar inflammatory cell infiltration and pulmonary edema, and ultimately ameliorating ALI (Figure 6).