In a recent experimental study, Dahl salt-sensitive rats without the NPR-A for specific genetic modification, exhibited increased BP when on a high-salt diet (4% NaCl for 21 days) and intensified hypertrophy and cardiac fibrosis (with no changes in ejection fraction) compared with hypertensive Dahl rats with functional NPR-A receptors [130]. The gene discussed is NPR1; the disease is cardiac hypertrophy.