NPPA and hypertensive disorder: Moreover, the single nucleotide polymorphism (SNP) rs5068 located in the three prime untranslated region (3′-UTR) of the ANP gene has a minor G allele associated with increased circulating levels of ANP, leading to reduced BP, reduced odds of hypertension and a favorable cardiometabolic profile, such as lower prevalence of obesity, type 2 diabetes and metabolic syndrome, all conditions favoring cardiac hypertrophy [47,48,49,50].